Research Article: The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

Posted 7/30/12 on PLOS, a very cool peer-reviewed, open access journal for the rest of us. A very nice US-based research article entitled "The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors" by Romano, et al.  This the life source for for HCV Drug Development and virology geeks alike. The authors look in-depth in the major resistance mutations at R155K, A156T, D168A and how they effect the binding of telaprevir, danoprevir, vaniprevir and MK-5172 to the HCV protease target. Also available as a PDF file at the PLOS site for an enthralling, page turning read (seriously!): http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002832